Frequently Asked Questions

  • What is the composition of Enriched Platelet Factors (EnPLAFTM)?

    EnPLAFTM is a technology to derive beneficial biological factors (proteins) from patient's own blood platelets. EnPLAFTM products are rich in growth factors but do not contain any live cells.

    • Platelet-derived growth factor (PDGF)
      Cell growth, Collagen production, new generation and repair of blood vessels
    • Vascular Endothelial Growth Factor (VEGF)
      Growth and new generation of vascular endothelial cells
    • Fibroblast Growth Factor (FGF)
      Tissue repair, Cell growth, Collagen production
    • Epidermal Growth Factor (EGF)
      Epithelial cell growth, promotion of wound healing, angiogenesis (formation of new blood vessels)
    • Transforming Growth Factor beta1 (TGF-B1)
      Growth of epithelial cells, endothelial cells, promotion of wound healing
    • Keratinocyte Growth Factor (KGF)
      Growth and new generation of keratinocytes (predominant cell type in the epidermis - the outer layer of skin)

    The beneficial biological factors secreted by platelets known to be important in healing, regeneration and pain reduction are:

  • How is EnPLAFTM derived? How soon can it be derived and administered?
    • A small amount of blood is drawn at the doctor's office by well trained staff.
    • EnPLAFTM will be derived from the patient's blood using our proprietary technique in a state-of-the-art laboratory as the patient waits at the doctor's office for about 2 hours. EnPLAFTM is administered by the doctor the same day.
    • Alternatively the patient can give their blood at their convenience and come back for the EnPLAFTM administration at a later appointment with the doctor.
    • Additionally from a single blood draw, we can prepare multiple EnPLAFTM products (as indicated by the doctor depending on your condition), then store them for future use. The additional EnPLAFTM will be properly labeled and stored in appropriate conditions by our staff until the patient is ready for injection.
  • Can I store my EnPLAFTM products for future use?

    Yes, EnPLAFTM products can be stored for future use. From a single blood draw NeoKine can prepare multiple EnPLAFTM therapies (as indicated by the doctor depending on patient condition), then store them for future use. The additional EnPLAFTM will be labeled and stored in appropriate conditions by our staff. The patient can come back for the EnPLAFTM administration at a later appointment with the doctor.

  • Does NeoKine offer EnPLAFTM therapy packages?

    The number of EnPLAFTM therapies a patient needs will be determined by the doctor depending on the patient's condition. The patient may need one or more EnPLAFTM therapies depending on their condition. NeoKine offers packages for multiple EnPLAFTM to be given over time, but for most packages patients will have to give blood only once. Please see 'Conditions treated' tab of this website to know more about therapy options for different conditions. Please talk to the doctor for more information.

  • How is Enriched Platelet Factors (EnPLAFTM) different than Platelet Rich Plasma (PRP)?

    Platelet Rich Plasma (PRP) is blood plasma with high levels of platelets-basically a concentrated source of autologous platelets. PRP has been used broadly in several areas of medicine and aesthetics to alleviate pain, reduce inflammation and initiate healing. The degranulation of platelets in an injury releases the biological factors into the local environment giving the beneficial effect.

    However, injection of live platelets present in PRP has several drawbacks:

    • PRP injections are painful
    • PRP cannot be stored without losing activity and potency. It has no shelf life and therefore must be administered almost immediately upon derivation
    • The process of deriving PRP does not have a standardized protocol; it varies from company to company. Therefore the quality and quantity of platelets and thus its biological effects are always variable in currently available PRP

    EnPLAFTM on the other hand is a technology to derive beneficial biological factors from patient's own blood platelets. Our EnPLAFTM products are rich in growth factors but do not contain any live cells.

    EnPLAFTM does overcome most of the problems associated with PRP:

    • EnPLAFTM does not have live platelets, so it is not painful
    • It has an excellent shelf life because it has no live cells, just biological factors
    • It can be stored for long without losing activity
    • It can be refrigerated or even frozen for future use
    • It retains activity after freeze-thaw, and thus has much better shelf life
    • It has higher concentration of factors
    • EnPLAFTM derivation has a standardized protocol for extraction – harvesting a fixed amount of product in each run. Total control. Total reliability
  • Why is EnPLAFTM better than conventional therapies?

    As compared to conventional therapies, EnPLAFTM :

    • Promotes faster healing and regeneration
    • Is harvested naturally from the patient’s own body
    • Has longer lasting effect
    • Is minimally invasive
    • Has minimal side effects
    • Has minimal to no down time
    • Can be stored for future use without losing potency
    • Single visit to the doctor can give you multiple EnPLAFTM which can be given over time for therapy
  • Are there any side effects of EnPLAFTM administration?

    Since EnPLAFTM is naturally derived from the patient's own blood, there is no risk of having an allergic reaction or any significant side effects from EnPLAFTM administration. Some local side effects like pain, swelling or infection at the site of injection may occur in some patients. Patients should contact the doctor immediately if they experience any side effect.

  • What are the contraindications for EnPLAFTM administration?
    Absolute Contraindications
    • Platelet dysfunction syndrome
    • Critical thrombocytopenia
    • Hemodynamic instability
    • Septicemia
    • Local infection at the site of the procedure
    • Patient unwilling to accept risks
    Relative Contraindications
    • Consistent use of NSAIDs within 48 hours of procedure
    • Corticosteroid injection at therapy site within 1 month
    • Systemic use of corticosteroids within 2 weeks
    • Tobacco use
    • Recent fever or illness
    • Cancer- especially hematopoietic or of bone
    • HGB < 10 g/dl
    • Platelet count < 105/ul

    Since EnPLAFTM is naturally derived from the patient's own blood, there is no risk of having an allergic reaction or any significant side effects from EnPLAFTM administration. Some local side effects like pain, swelling or infection at the site of injection may occur in some patients. Patients should contact the doctor immediately if they experience any side effect.

  • How soon do patients typically see improvement following EnPLAFTM procedure?

    Details for use of specific EnPLAFTM products in different medical and aesthetic indications is also discussed under the 'Conditions treated' section of this website.

    Generally, patients can expect gradual improvement starting the first two weeks after EnPLAFTM administration. The complete effect of the procedure will be known within three to six weeks after the last EnPLAFTM administration, depending on an individual's healing capacity. Certain patients may need one or more EnPLAFTM administrations. Depending on the severity and chronicity of their condition, results of the procedure may vary by individual.

  • Is PRP therapy or EnPLAFTM therapy approved by the FDA?

    No, neither are approved by the FDA at this time.

  • Does insurance cover PRP therapy or EnPLAFTM therapy?

    No, neither are covered by the insurance companies at this time.